Xiao-Jiang Li Selected Research

tributyl phosphate (TBP)

1/2020	Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17.
10/2019	Molecular Mechanisms and Therapeutics for SCA17.
1/2017	Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17.
1/2017	Genetically modified rodent models of SCA17.
1/2014	Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.
11/2009	Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17.
10/2009	Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection.
12/2007	Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration.

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Xiao-Jiang Li Research Topics

Disease

63	Huntington Disease (Huntington's Disease) 11/2022 - 03/2002
34	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 03/2002
7	Spinocerebellar Ataxia 17 01/2018 - 12/2007
6	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 04/2014
6	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2020 - 03/2008
5	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 05/2014
5	Disease Progression 10/2019 - 03/2003
4	Nervous System Diseases (Neurological Disorders) 11/2021 - 12/2008
3	Body Weight (Weight, Body) 01/2017 - 05/2006
3	Nasopharyngeal Carcinoma 12/2016 - 07/2008
3	Neoplasms (Cancer) 01/2014 - 07/2008
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 04/2015
2	Autistic Disorder (Autism) 10/2019 - 01/2019
2	Inflammation (Inflammations) 01/2017 - 07/2009
2	Fever (Fevers) 04/2013 - 04/2008
2	Glucose Intolerance 04/2012 - 03/2003
2	Lymphatic Metastasis 07/2008 - 08/2005
2	Carcinoma (Carcinomatosis) 04/2008 - 08/2005
1	Postoperative Pain 11/2022
1	Infections 11/2022
1	Cicatrix (Scar) 11/2022
1	Demyelinating Diseases (Demyelinating Disease) 01/2020
1	Multiple Sclerosis 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 11/2019
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 10/2019
1	X-Linked Bulbo-Spinal Atrophy 10/2019
1	Autism Spectrum Disorder 01/2019
1	Down Syndrome (Down's Syndrome) 01/2017
1	Ataxia (Dyssynergia) 01/2017
1	Hyperphagia (Overeating) 01/2017
1	Insulin Resistance 01/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2016
1	Muscular Dystrophies (Muscular Dystrophy) 07/2015
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 07/2015
1	Anorexia 12/2014
1	Lung Neoplasms (Lung Cancer) 12/2014
1	Cachexia 12/2014
1	Urologic Diseases (Urinary Tract Disease) 04/2013
1	Prostatic Neoplasms (Prostate Cancer) 04/2013
1	Encephalitis (Encephalitis, Rasmussen) 07/2009
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2008
1	Agenesis of Cerebellar Vermis 08/2008
1	Neoplasm Metastasis (Metastasis) 07/2008
1	Neoplasm Micrometastasis 07/2008

Drug/Important Bio-Agent (IBA)

53	polyglutamineIBA 01/2020 - 03/2002
49	Proteins (Proteins, Gene)FDA Link 12/2021 - 05/2002
8	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2020 - 12/2007
8	tributyl phosphate (TBP)IBA 01/2020 - 12/2007
5	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 05/2014
3	Therapeutic UsesIBA 01/2020 - 04/2008
3	Insulin (Novolin)FDA Link 01/2017 - 05/2006
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2016 - 03/2003
3	Glutamine (L-Glutamine)FDA Link 06/2012 - 06/2008
2	Phosphotransferases (Kinase)IBA 01/2022 - 01/2017
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 10/2019
2	Amino Acids FDA Link 01/2016 - 10/2010
2	Huntingtin ProteinIBA 01/2016 - 03/2004
2	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2015 - 03/2008
2	LeptinIBA 12/2014 - 05/2006
2	UbiquitinIBA 04/2014 - 03/2008
2	Glucose (Dextrose)FDA LinkGeneric 04/2012 - 03/2003
1	laquinimodIBA 01/2020
1	Amyloid (Amyloid Fibrils)IBA 11/2019
1	Valproic Acid (Depakote)FDA LinkGeneric 10/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	Mutant Proteins (Protein, Mutant)IBA 01/2018
1	Dyrk KinasesIBA 01/2017
1	Crystallins (Crystallin)IBA 01/2017
1	Nerve Growth Factors (Neurotrophins)IBA 01/2017
1	Interleukin-10 (Interleukin 10)IBA 12/2016
1	I-antigenIBA 12/2016
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	Nuclear Proteins (Protein, Nuclear)IBA 09/2015
1	DystrophinIBA 07/2015
1	SynucleinsIBA 04/2015
1	BerberineIBA 01/2015
1	Neuropeptide YIBA 12/2014
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 12/2014
1	Lysine (L-Lysine)FDA Link 04/2014
1	ZincIBA 04/2014
1	CopperIBA 04/2014
1	Superoxide Dismutase-1IBA 04/2014
1	Tamoxifen FDA LinkGeneric 01/2014
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2014
1	Hemoglobins (Hemoglobin)IBA 04/2013
1	Prostate-Specific Antigen (Semenogelase)IBA 04/2013
1	Interleukin-1 (Interleukin 1)IBA 11/2010
1	OrexinsIBA 05/2010
1	brain-derived neurotrophic factor precursorIBA 02/2010
1	Adenosine Triphosphate (ATP)IBA 07/2009
1	Adenosine (Adenocard)FDA LinkGeneric 07/2009
1	Protein AggregatesIBA 11/2008
1	Imatinib Mesylate (Gleevec)FDA Link 10/2008
1	Tyrosine Kinase InhibitorsIBA 10/2008
1	Hyaluronic Acid (Hyaluronan)IBA 07/2008
1	Endothelial Growth FactorsIBA 07/2008
1	Vascular Endothelial Growth Factor CIBA 07/2008

Therapy/Procedure

9	Therapeutics 11/2022 - 03/2003
2	Thyroidectomy 11/2022 - 08/2005
1	Operative Time 11/2022